In order to gain insight as to when GM-CSF signalling is required during an inflammatory reaction we next explored whether in the AIP model a therapeutic delivery (at day 2) of CAM-3003 after antigen challenge was effective and, if so, was it in anyway more effective if an additional prophylactic delivery (at day -1) was given, the latter protocol being similar to that employed above in the AIA model (Fig. 2). Here, CSF2 is linked to autoimmune pancreatitis.