Utilizing the stable HCT-15/Rluc cell lines (HCT-15/RLuc/eIF4E, HCT-15/Rluc/VEGF-C, HCT-15/Rluc/MMP-2, HCT-15/Rluc/E-cadherin and parental HCT-15/Rluc, Figure 4A), we investigated the effect of eIF4E, VEGF-C, MMP-2 and E-cadherin on the colon cancer cell growth. This evidence concerns the gene MMP2 and colonic neoplasm.