Of note, immunostaining of skin biopsies derived from cSCC patients (Supplementary Figure S6) revealed that a large number of Chemerin-releasing FSP-1+ fibroblasts (30.83 % ± 1.89 of total stromal cells) were present in the cSCC tumor stroma of older patients (age 80 ± 5 years, n = 5 cSCC patients) as compared to younger cSCC patients (16.04 ± 3.2 total stromal cells, age 54 ± 5 years, n = 5 cSCC patients). Here, RARRES2 is linked to skin squamous cell carcinoma.