TP53 and Lynch syndrome: Furthermore, Sotamaa et al. reported that TP53 polymorphisms may not be associated with CRC development in patients with Lynch syndrome [18]; this finding is consistent with that of Talseth et al. However, a cohort study conducted in the United States reported that patients with Lynch syndrome carrying the heterozygous genotype rs1042522 developed CRC 13 years earlier in life than those carrying the homozygous wild-type genotype did [19].