For example, (5S,7S)-7-methyl-3-(3-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydrocinnolin-5-ol (NK150460) suppresses growth of different estrogen receptor (ER)-negative and ER-positive breast cancer cell lines via the molecular cascade of Ahr/Arnt [11]. Here, ESR1 is linked to breast cancer.