The evaluation of the cytotoxicity of the EEHS in Kasumi-1 cells labeled with annexin V-FITC/PI indicated a decrease in the viability of tumor cells in late apoptosis (Fig 5B and 5C) by 21.6% and 78.7% at concentrations of 100 μg/mL and 200 μg/mL, respectively, and the IC50 was 160 μg/mL (Fig 5A). This evidence concerns the gene ANXA5 and neoplasm.