There is evidence that Galanin (Gal) and its three general receptor subtypes known as GalR1, GalR2 and Gal R3, play a significant role in anxiety, depression, and stress-like behaviors through modulation of neuroendocrine, serotonergic and noradrenergic systems [10–13]There are also reports suggesting that Gal has antidepressant effects[14] [15]. Here, GALR3 is linked to major depressive disorder.