GalR1 and GalR2 are expressed throughout the brain [48],while GalR3 is confined to the hypothalamus [49] It has been postulated that the dysregulation of the normal interaction between NE and Gal in the amygdala may contribute to stress-related disorders, such as depression, anxiety and PTSD [22]. The gene discussed is GALR2; the disease is major depressive disorder.