This study provides a baseline to develop a better understanding of mutant MFN2 pathology and further studies are planned to establish whether or not this pathology results from decreased axonal transport including the potential involvement of more distal tibial nerve branches innervating musculature in the foot as well as investigating sensory nerve involvement in our model of pes cavus using both ultrastructural analysis (e.g. sural nerve) and functional sensory testing (e.g. Von Frey analysis testing foot withdrawal to filaments). The gene discussed is MFN2; the disease is Pes cavus.