At 24 h after B. melitensis 16M infection, NLRP3 and AIM2 in the I-A, O-A, and OA-IA cells were lower than in the control group and NLRP3 and AIM2 in the I-A cells were significantly different from those in the OA-IA cells (P < 0.01), suggesting B. melitensis 16M infection inhibited NLRP3 and AIM2 inflammasome activation. This evidence concerns the gene NLRP3 and infection.