ATM and Hutchinson-Gilford progeria syndrome: Attempts to increase H3K9me3 through methylene blue (MB), an antioxidant which has been recently reported to remove progerin from the nuclear rim and rescue heterochromatin loss in HGPS [33], was able to restore H3K9me3, rescue the defects in ATM activation, gammaH2AX signal strength, and DDR in HGPS fibroblasts.