TSC2 and Angiofibromas: Tuberous Sclerosis Complex (TSC) is an autosomal dominant genetic disorder due to inactivating mutations in either TSC1 or TSC2. There are well-established consensus diagnostic criteria for TSC; the major clinical criteria include angiofibromas or fibrous cephalic plaque, ungual fibromas, shagreen patch, angiomyolipomas, and lymphangioleiomyomatosis [1].