To attempt to develop a mouse model of Shagreen patch, cephalic patch, facial angiofibroma, ungual fibroma, renal angiomyolipoma, and/or lymphangioleiomyomatosis, we used an Fsp-cre transgene [10] to drive loss of Tsc1 in fibroblasts in mice in vivo. The gene discussed is TSC1; the disease is lymphangioleiomyomatosis.