The median bacterial load in the kidneys that reflects the ability of the host to clear the bacteria was lower in RAGE-/- mice compared to WT mice (median 6.9x105; interquartile range (IQR) 1.0.x102–8.0x106 CFU versus 14x105; IQR 2.5x104–4.6x106 CFU, respectively) in the septic arthritis experiment (Fig 1D). The gene discussed is AGER; the disease is bacterial arthritis.