AGER and Sepsis: In terms of the sepsis experiment, the median bacterial load resulted in significantly higher bacterial counts in the RAGE-/- group compared to the WT group (median 6.1x107; IQR 3.6x107 – 15x107 CFU versus 2.2x107; IQR 0.6x107–2.7x107 CFU, respectively, p = 0.0085)(Fig 1D).