The mean arthritis severity reached its peak on day 10 for RAGE-/- mice and on day 12 for its WT counterpart being almost identical in both groups at the end of experiment (1.06 ± 0.28 in RAGE-/- and 1.07 ± 0.26 in WT mice, respectively)(Fig 1A). The gene discussed is AGER; the disease is arthritic joint disease.