PPARGC1A and sarcopenia: Moreover, it was shown that a higher expression of muscle peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a major factor that controls mitochondrial biogenesis and respiration, protects from sarcopenia during aging [19] and that PGC-1α expression was increased in SAMP1 mice by dietary supplementation of reduced CoQ10 (ubiquinol) [20].