When we compare the results of our mouse study with the results of the SMA infant study, 2 of the 5 SMN-responsive protein analytes in the mouse study, DPPIV and tetranectin, showed the same direction of change in SMA mice compared with the infants with SMA, 2 were not changed in SMA infants, and 1 was not performed (Table 3). This evidence concerns the gene CLEC3B and proximal spinal muscular atrophy.