CD33 and acute myeloid leukemia: [14] Finally, albeit never performed in the clinical setting, our future plan is to investigate the utility of iC9-CAR.CD33 T-cells as part of the conditioning therapy for an allo-HSCT for AML, together with other myelosuppressive agents, whilst the activation of the iC9 suicide gene would grant elimination of the infused gene modified T-cells prior to stem cell infusion to reduce the risk of engraftment failure as CD33 is also expressed in a proportion of the donor stem cell graft.