The expressions of mRNAs of CAMK1 (aortic valve disease, n = 7, normal subjects, n = 6; 18.89±0.23 vs. 17.43±0.43, P = 0.032) and PPP3R1 (aortic valve disease, n = 7, normal subjects, n = 6; 13.95±0.21 vs. 13.06±0.27, P = 0.032) in the left atrial free wall were significantly down-regulated in patients with aortic valve disease compared to normal subjects (Fig 5). Here, CAMK1 is linked to aortic valve disorder.