PPP3R1 and cardiac hypertrophy: A network with highest score (P-score = 50, i.e. P value < 10−50) was generated from 244 differentially expressed genes using Ingenuity Pathway Analysis Global Molecular Network algorithm as depicted in Fig 2, and 26 focused genes were identified to be involved in the network, including PLCE1, PPP3R1, PPP3CB, MEF2C and etc. Top involved canonical pathways in this network included role of nuclear factor of activated T cells (NFAT) in cardiac hypertrophy, cardiac hypertrophy signaling, and calcium signaling (Table 5).