However, the pooled data demonstrated that PLR was not significantly correlated with other 5 clinicopathological factors including lymph node metastasis (OR=1.23, 95% CI = 0.88–1.73, p = 0.229), unclear grade (OR=0.94, 95% CI = 0.48–1.84, p = 0.859), estrogen receptor (ER) status (OR=0.93, 95% CI = 0.78–1.11, p = 0.42), progesterone receptor (PR) status (OR= 0.88, 95% CI = 0.73–1.06, p = 0.168) or AJCC stage (OR=1.51, 95% CI = 0.85–2.67, p = 0.158). Here, ESR1 is linked to metastatic malignant neoplasm in the lymph nodes.