FLT3 and colorectal cancer: Recently, a refractory colorectal cancer patient with FLT3 amplification using targeted genomic profile (FoundationOne) demonstrated clinical benefit with sorafenib, a multikinase inhibitor targeting vascular endothelial growth factor receptors (VEGFR) 1 to 3, FLT3, platelet-derived growth factor receptor (PDGFR), c-Kit protein (KIT), and RET receptor tyrosine kinases [12].