Multivariable analysis showed that low pre-albumin level (HR, 1.85;P=0.013) was an independent predictor of CSS, along with age greater than 65 (HR, 2.49; P<0.001), tumor multifocality (HR, 1.81; P=0.017), pT stage(HR, 3.08; P<0.001), grade(HR, 2.28; P=0.004), LVI(HR, 1.77;P=0.012), but hypoalbuminemia was not. The gene discussed is ALB; the disease is Hypoalbuminemia.