As to OS, multivariable analysis also demonstrated that low pre-albumin level (HR, 1.73;P=0.015) was an independent predictor, along with age greater than 65 (HR, 3.03; P<0.001), tumor multifocality (HR, 1.85; P=0.007), pT stage (HR, 2.35; P<0.001), pN stage(HR, 1.94; P=0.029), grade(HR, 1.88; P=0.007), LVI(HR, 1.56;P=0.032), but hypoalbuminemia was not. This evidence concerns the gene ALB and Hypoalbuminemia.