In a multivariate cox regression analysis including the 40 patients with high stage ccRCC and the variables CK2α nuclear expression, Fuhrman grade G1-G2/G3-G4, tumor size <7/≥7 cm, VHL mutation and gender, nuclear expression of CK2α lost its prognostic value (Table 4). Here, VHL is linked to nonpapillary renal cell carcinoma.