They furthermore analyzed the importance of CK2 activity on the proliferation of renal cancer cells in 786-O RCC cells (786-O WT) or isogenic 786-O cells either reconstituted with functional VHL (786-VHL) or expressing the empty expression vector pBABE (786-O pB) and exposed them for increasing concentrations of CX-4945. Here, VHL is linked to renal cell carcinoma.