After 24 h entering the internode small vessels, these RFP-HepG2 cells presented different cell fates (Figure 3D and 3E), some tumor cells remained quiescence, some developed apoptosis (Figure 3F, Apop) or fragmented (Figure 3F, Frag), some tumor cells with strong transfer ability penetrated and extravastated out of host vascular vessels and entered into adjacent tissues within 24 h (Figure 3F, Ex). This evidence concerns the gene COA8 and neoplasm.