PLOD1 and hepatocellular carcinoma: Honokiol was also reported to show toxic to many other cancer cells [17–27], but our results show LH (≤ 40 μM)showed no toxic to HCC cells, that was because honokiol may have many molecular targets in cancer cells and different cancer cells relays on different signal pathways for survival, so honokiol could show different activities in different cancers.