In the present study, we for the first time demonstrated that LH possessed potent anti-metastasis properties for HCC cells at non-toxic concentrations by destabilizing EGFR and inhibiting the downstream metastasis related PI3K/Akt, ERK and JNK pathway, which maybe a non-toxic anti-metastasis drug in a clinical setting. This evidence concerns the gene MAPK8 and hepatocellular carcinoma.