Thus, we hypothesized that PRR14 may be a novel oncogene activating the PI3-kinase/Akt/mTOR signal pathway, which is known to regulate mammalian cell size through generic gene expression8, 9 and a commonly activated pathway in lung cancer.10 Consistent with this, the high expression of PRR14 significantly associates with a decreased 5-year survival rate in more than 1900 lung cancer patients. Here, PRR14 is linked to lung cancer.