In the latter gene network shown in Figure 2, sPIF specifically downregulated BAX, CECR2 (coding for Cat Eye Syndrome Chromosome Region, Candidate 2), INHBA (coding for inhibin beta A) and upregulated BCL2, F7 (coding for coagulation factor VII) and GRN (coding for granulin) in human EVT. This evidence concerns the gene MROH2B and cat-eye syndrome.