AVA-induced G1-phase cell cycle arrest in AML cells consistent with an increase in p53 and p21 levels demonstrated previously to directly or indirectly induce cell cycle arrest.42 Although the presence of wt p53-sensitized AML cells toward AVA, higher doses inhibited proliferation of p53-reduced, p53-null or p53-mutated cells. This evidence concerns the gene TP53 and acute myeloid leukemia.