We have showedthat Bcl-3 stabilizes c-Myc protein and promotes colorectal cancer development byregulating ERK signaling.22 Bcl-3 wasrecently reported to promote colorectal tumorigenesis through activation of AKTsignaling.28 The above evidencereveals that Bcl-3 has many novel roles in tumor development and progression beyondbeing a trans-activator or trans-repressor. Here, BCL3 is linked to colorectal cancer.