Comparable volumes ofprimary tumors from both Bcl-3-sufficient andBcl-3-deficient breast cancer cells were observed (data not shown).However, the number of metastatic pulmonary nodules was significantlyreduced in mice injected with cancer cells from Bcl-3-nullMMTV-PyMT mice compared with WT MMTV-PyMT mice (Figure2e). The gene discussed is BCL3; the disease is breast cancer.