Wound-healing assayshowed that Bcl-3 depletion significantly reduced cell migration comparedwith control cells in LM2 and 4T1 cells (Figures 3e andf and Supplementary Figure 6b).Together, these results suggest that Bcl-3 promotes the pulmonary metastasisof breast cancer cells by regulating the migration and invasion of breastcancer cells. The gene discussed is BCL3; the disease is breast cancer.