We have previously reported that Bcl-3 was upregulated in human colorectalcancer compared with normal tissues.22 Bcl-3 expression has increased in breast cancerscompared with normal mammary tissues.29,30 Here we assessedBcl-3 mRNA expression levels based on the Cancer Genome Atlas(TCGA) breast cancer (BRCA) data31and the expression of Bcl-3 mRNA in tumors was much higher thantumor-matched normal tissues (n=99) (Figure 1a). This evidence concerns the gene BCL3 and breast cancer.