Nonetheless, according to reports, AS1517499 (UNII-2H31HOT08T), soluble in purified DMSO, is a potent and selective STAT6 inhibitor with an IC50 of 21 nM.46 This compound is a novel p-STAT6 inhibitor that was synthesized based on the structure of a previously reported STAT6 inhibitor, TMC-264, discovered from the fungus Phoma. 47, 48 We used AS1517499 1 h before the second immunization with Ad-TSHR289, when the mice already had some symptoms of GD, such as mild thyromegaly and slight but significant increases in T3 and T4 (data not shown). The gene discussed is STAT6; the disease is goiter.