Finally, in a multivariate Cox model including age, gender, tumor grade, lymph node invasion, ERBB3 expression, DNMT1 expression and miR-148a-3p expression, we found that ERBB3 overexpression was a poor independent prognostic factor for the overall survival in patients with bladder cancer (P=0.044, Table 2). The gene discussed is ERBB3; the disease is urinary bladder cancer.