PRKN and Parkinson disease: Parkin has been shown to initiate ubiquitination of numerous OMM proteins, to initiate selective autophagy, and to function in the degradation of damaged mitochondria.8, 13, 14, 15, 16 PINK1 kinase activity is required to induce the translocation of Parkin to depolarized mitochondria, and several mutations in the pink1 gene that yield stable PINK1 that lacks kinase activity have been associated with Parkinsonisms.17, 18, 19