INTU and neoplasm: Our results demonstrate that expression of Int-αvβ3, previously shown to play a role in tumor progression (reviewed in ref. 33), can surprisingly promote differentiation of CLPslow in conjunction with their microenvironment into (i) a precancerous stage resembling human UDH when placed in the 3D BME system (ii) and to a more differentiated phenotype when introduced in vivo into a supportive microenvironment of human origin.