Intriguingly, tumors developed by MCF-7-Intβ3 cell were highly differentiated compared with MCF-7 tumors, grown in an in vivo humanized mouse model.13, 14 All together, these findings demonstrate for the first time to our knowledge that CLPs, which are present in luminal A breast cancer cell lines and tissues,15 can be induced to differentiate into acinar-like organoids via expression of Int-αvβ3 in the 3D system and in vivo to a more differentiated phenotype. This evidence concerns the gene INTU and breast carcinoma.