CASP2 and B-cell chronic lymphocytic leukemia: For instance, CASP2 on human Ch7q is frequently deleted in haematological malignancies5 and reduced CASP2 expression is noted in Burkitt's lymphoma, mantle cell lymphoma, chronic lymphocytic leukaemia (CLL) and hairy cell leukaemia, and correlates with poor prognosis in acute myeloid leukaemia (AML) and acute lymphocytic leukemia (ALL).6, 7, 8 In The Cancer Genome Atlas (TCGA) (http://cancergenome.nih.gov/) and BloodSpot databases, lower CASP2 expression is clearly linked to poor patient survival in AML (http://servers.binf.ku.dk/bloodspot/?gene=CASP2&dataset=normal_human_v2_with_AMLs).