NFE2L2 and Alzheimer disease: The upregulation of α-secretase transcription is potentially mediated by Nrf2 activation, but CA has been shown to activate other transcriptional pathways as well.7 In addition, activation of Nrf2 has been shown to decrease the level of phospho-tau protein,26 which is thought to mediate neuronal damage in AD downstream of aberrant Aβ activity.27