Serine to aspartate conversions at these sites render the transcriptional activity of PAX3/FOX1A fusion proteins insensitive to the inhibitory actions of the kinase inhibitor PKC412, which inhibits growth of alveolar rhabdomyosarcomas carrying a Pax3/Fox1A translocation (Amstutz et al., 2008). Here, PAX3 is linked to alveolar rhabdomyosarcoma.