Quantitation showed that cultures of myogenic cells from healthy controls, as well as from MDC1A, LGMD2D, and FSHD donors, all showed similar decreases in the number of PML bodies in myotube nuclei compared to myoblast nuclei (Fig. 3c). The gene discussed is LAMA2; the disease is autosomal recessive limb-girdle muscular dystrophy type 2D.