However, no correlation was found between concentrations of Ang-1 and Ang-2 or Ang-2/Ang-1 ratio and sequestration in cerebral malaria in brain autopsies [33], microvascular obstruction measured with an Orthogonal Polarization Spectral device in the rectal mucosa [46] or rosetting as determined by IgG antibody levels to the infected erythrocyte surface of ex vivo isolates and corrected for disease severity [49]. This evidence concerns the gene ANGPT1 and cerebral malaria.