Furthermore, an elevated Ang-2 concentration was associated with respiratory distress [49], impaired consciousness [49], acute kidney injury [33, 46], multi-organ failure [46], anaemia [33], jaundice [33], hypoglycaemia [33], pure cerebral malaria (cerebral malaria patients without the other complications of severe malaria according to WHO 2000 criteria) [33] and higher Ang-1 levels were associated with a higher platelet count in P. falciparum and P. vivax infections [31, 33, 50]. This evidence concerns the gene ANGPT2 and anemia.