ANGPT2 and Plasmodium vivax malaria: Differences in the absolute Ang-1 and Ang-2 concentrations were also found between disease severity states: lower Ang-1 and higher Ang-2 concentrations were observed in severe disease compared to uncomplicated disease in both falciparum [25, 28–30, 32, 34, 43–45] and vivax malaria [31, 43] and in non-survivors compared to survivors infected with P. falciparum [25, 27, 30, 32–35, 41, 46] (see Additional files 3, 4, 5, 6).