Incorporating the Ang-2 concentration or the Ang-1, Ang-2 and Tie-2 concentrations in a clinical model, comprising age, body condition score, respiratory distress, and severe anaemia as other parameters, significantly improved the ability to accurately predict survival or fatal outcome compared to the clinical model alone (c-index (95% CI), p value) (i: 0.78 (0.68–0.82), 0.02; ii: 0.79 (0.72–0.84), 0.03) [27]. The gene discussed is ANGPT1; the disease is anemia (phenotype).