In ten out of eleven studies comparing healthy controls with either uncomplicated [25, 32, 34, 35, 37, 43–45], severe [34, 35, 43, 45, 46] or cerebral falciparum malaria [25, 32, 37, 44, 45] or uncomplicated [43, 47] or severe [43] vivax malaria, a similar pattern in changes was observed for Ang-1 and Ang-2 levels: a decrease of Ang-1 [25, 32], an increase of Ang-2 [25, 32, 34, 35, 37, 43–47] and consequently an increase of the Ang-2/Ang-1 ratio [25, 32] (see Additional files 3, 4, 5). This evidence concerns the gene ANGPT2 and Plasmodium vivax malaria.