Since cerebral malaria is a complication of falciparum malaria and therefore a manifestation of severe malaria, distinguishing cerebral malaria from other forms of severe malaria was difficult, as shown by the observation that only the Ang-1 concentration had a predictive value significantly higher than chance [28] with a sensitivity of 72% (95% CI 56–84) and specificity of 66% (95% CI 55–75). Here, ANGPT1 is linked to Plasmodium falciparum malaria.