Multi-targeted adjuvant treatment, such as rosiglitazone, that (unlike FTY720 or iNO) was found to have an effect on Ang-1 and Ang-2 levels and survival when administered post-infection, may however interfere with all the distinct regulatory systems in a way that reduces morbidity and mortality [26] (see Fig. 2), although further studies are definitely needed. This evidence concerns the gene ANGPT2 and infection.