When sub-grouping these cirrhotic patents according to Child-Turcotte-Pugh classification, an increasing EMR2 expression on neutrophil was noted as the severity of liver cirrhosis progress when comparing that with healthy volunteers (MFI of EMR2: Child-Turcotte-Pugh A vs. B vs. C vs. healthy volunteers: 23.74 ± 11.15 vs. 33.97 ± 18.00 vs. 39.89 ± 24.95 vs. 18.38 ± 7.74; p < 0.0001, Fig. 1B and Table 1). This evidence concerns the gene ADGRE2 and cirrhosis of liver.