After artificial selection regions showed differentiation between the LH and HF groups, such as 15.23–15.30 MB (ZFst = 3.769) in chromosome 10, 26.70–26.85 MB (ZFst = 3.769) in chromosome 25, 26.78–26.85 MB (ZFst = 3.6286) in chromosome 25, and 58.50–58.65 MB (ZFst = 3.6286) in chromosome X, which contained CORO2B (coronin, actin binding protein, 2B), TRNAR-UCG (transfer RNA arginine, anticodon UCG), ITGAL (integrin alpha L), ZNF768 (zinc finger protein 768), ZNF689 (zinc finger protein 689) and DACH2 (dachshund family transcription factor 2) (Fig. 2B). The gene discussed is PLOD1; the disease is hydrops fetalis.