WSPAR and hepatocellular carcinoma: In addition, we observed that depletion of both lncTCF7 and lncBRM more significantly impaired oncosphere formation than lncTCF7 or lncBRM depletion alone (Supplementary Fig. 7C), suggesting that targeting both lncTCF7 and lncBRM may be better than lncBRM or lncTCF7 alone for potential therapy of HCC patients.