MTHFR and hyperinsulinemic hypoglycemia, familial, 4: Dementia, behavioural problems and psychiatric symptoms have frequently been observed in the combined (Roze et al 2003; Liu et al 2015; Huemer et al 2014) as well in isolated remethylation disorders (Huemer et al 2015a) and MTHFR deficiency (Birnbaum et al 2008).