CD274 and melanoma: In a study of previously untreated melanoma, median PFS (mPFS) in response to ipilimumab was unaffected by PD-L1 status (PD-L1 positive 3.9 months, 95% CI 2.8 to 4.2 months versus PD-L1 negative 2.8 months, 95% CI 2.8 to 3.1 months) while response to nivolumab was influenced by PD-L1 status (14.0 months, 95% CI 9.1 to not reached versus 5.3 months, 95% CI 2.8 to 7.1 in PD-L1 positive versus PD-L1 negative tumors, respectively) [43].