CD4 and systemic lupus erythematosus: We have unraveled that H3K4me3 enrichment at the CREMα promoter was elevated in SLE CD4+ T cells, therefore we further investigated whether the levels of DNA methylation, DNMT3a, H3ac, and H4ac at this region were affected by the alter of H3K4me3 in these SLE CD4+ T cells whose Set1 had been knocked down.