Consequently, we unraveled that DNMT3a binding at the CREMα promoter was decreased greatly in SLE CD4+ T cells (Fig. 5b, Additional file 1: Table S2), and H3K4me3 enrichment was also negatively correlated with the amount of DNMT3a (Fig. 5c). This evidence concerns the gene CD4 and systemic lupus erythematosus.