It is well known that H3K4me3 can suppress DNA methylation and induce histone acetylation [11, 13, 16, 44, 45], so whether the changed H3K4me3 enrichment will alter the levels of DNA methylation and histone acetylation at the CREMα promoter in SLE CD4+ T cells is still in question. The gene discussed is CD4; the disease is systemic lupus erythematosus.