HDAC3 activity was significantly and positively correlated with fasting plasma glucose (r = 0.611, p < 0.001), HbA1c (r = 0.474, p = 0.001), and insulin resistance HOMA-IR (r = 0.526, p < 0.001) HDAC3 activity also showed positive correlation with circulating TNF-α (r = 0.534, p < 0.001) and IL-6 (r = 0.617, p < 0.001). This evidence concerns the gene HDAC3 and Insulin resistance.