When analyzed for gender, HDAC3 activity was increased (p < 0.001) to the extent of 2.7-fold in females (Fig. 3c) while it was 2.1-fold increased (p < 0.001) in male patients with T2DM (Fig. 3b) compared to their counterpart control subjects. This evidence concerns the gene HDAC3 and type 2 diabetes mellitus.