As PBMCs serve as a potentially accessible surrogate cell model to study the pathogenesis of diabetes and its complications [22], our study using PBMCs as a proxy for demonstrating the epigenetic alterations with special reference to HDAC3 and inflammation is significantly important as these cells infiltrate peripheral organs/tissues and culminate in the etiology of type 2 diabetes. The gene discussed is HDAC3; the disease is type 2 diabetes mellitus.