TIMP1 and acute myeloid leukemia: Interestingly, when we analyzed the levels of TIMP-1 in the supernatants of co-cultures of AML cells with leukemic or normal MSCs, we found that TIMP-1 level was higher in presence of HD-MSCs over AML-MSCs (263 ± 19.68 ng/ml and 162 ± 24.43 ng/ml, respectively; p ≤ 0.05; Figure 7B).