TIMP1 and acute myeloid leukemia: Pre-incubation of AML cells with LY294002 plus TIMP-1 significantly decreased their clonogenic output as compared to TIMP-1 alone (p ≤ 0.05) (Figure 6A), reverted TIMP-1-mediated anti-apoptotic activity (p ≤ 0.0001) (Figure 6B) and its migratory capacity on AML cells (Figure 6C) (p ≤ 0.0001).