AKT1 and ovarian cancer: Moreover, the results on dual DYRK1B-PI3K/AKT/mTOR/S6K inhibition were not specific to Panc1 cells as we could reproduce them in Ovcar-3 ovarian cancer cells using combinations of AZ191 and inhibitors targeting PI3K, mTOR, AKT and S6K (Supplementary Figure S8A–S8E).