The most enriched pathways were Alzheimer disease-presenilin pathway, angiogenesis, biotin biosynthesis, CCKR signaling map, cytoskeletal regulation by Rho GTPase, gonadotropin-releasing hormone receptor pathway, inflammation mediated by chemokine and cytokine signaling pathway, nicotine degradation, PDGF signaling pathway, VEGF signaling pathway, and Wnt signaling pathway (Figure 4B). Here, GNRHR is linked to early-onset autosomal dominant Alzheimer disease.