Figure 5e shows that ICON was equally effective in killing CD133+ CSCs and CD133- non-CSC breast cancer cells isolated from surgically dissected primary tumor tissues from patients, while IgG isotype negative control showed no effect in killing any cancer cells (p value not significant for CSCs vs. non-CSCs; p<0.0001 between ICON and IgG isotpye control for CSCs and non-CSCs). This evidence concerns the gene PROM1 and cancer.