ICON could augment CD16+ effector cell-mediated ADCC to kill CD133+ CSCs and CD133- non-CSC H460 lung cancer cells (no significant difference between CD133+ and CD133- cells) (Figure 5a), whereas human IgG control antibody showed no ADCC effect on those cancer cells (p<0.001 between ICON and IgG control). This evidence concerns the gene PROM1 and cancer.