Notably, treatment with imatinib did not affect the phosphorylation of c-Abl on Tyr-245 in NB cells [33], whereas bosutinib significantly abrogated p-c-Abl (Y245) level in a subset of NB cells used in this study and in SH-SY5Y xenografted NB tumor tissue. The gene discussed is ABL1; the disease is neoplasm.