RPS6KB1 and lung cancer: Combined, but not individual, treatment of lung cancer cells strongly increased the phosphorylation of eIF2α S51, ATG13 S318, JNK and p38 whereas it decreased the phosphorylation of AKT T308, p70 S6K T389, mTOR S2448 and ULK-1 S757 (Figure 3A and 3B).