CFLAR and neoplasm: Reduced chaperone function in a tumor cell would facilitate the inactivation of multiple cyto-protective signaling modules such as the PI3K-AKT-mTOR pathway and lower expression of protective proteins with short half-lives e.g. MCL-1 and c-FLIP-s, as well as facilitating an unfolded protein response that promoted the formation of toxic autophagosomes.