HMMR and brain neoplasm: HA abundance in brain tumors has been known to promote motility of GBM cells by providing mechanical stiffening and acting as a ligand for intracellular signal transduction through its cognate receptors such as such as cluster determinant 44 (CD44), receptor for hyalunonate-mediated motility (RHAMM), and intercellular adhesion molecule-1 (ICAM-1) [5, 7, 8].