AML with t(8;21)(q22;q22) [RUNX1-RUNX1T1] and inv(16)(p13.1q22) or t(16;16)(p13.1;q22) [CBFB-MYH11], which the aberrant fusion genes leaded to impaired differentiation of hematopoietic progenitors, commonly referred to as core-binding factor (CBF)–CAML. The gene discussed is RUNX1; the disease is acute myeloid leukemia.