EBNA3A and EBNA3C together specifically repress, among many other host genes, pro-apoptotic BIM/BCL2L11 (7) and anti-proliferative p16INK4A (8–10) two tumor suppressors that would otherwise contribute to an oncogenic stress response resulting from virus-induced cell activation and proliferation (6,11–13). This evidence concerns the gene BCL2L11 and neoplasm.